Does Notepad++ support column mode selection?

Yes. Alt-Shift-Arrow keys or Alt + left mouse click. See Shortcuts page to get all Notepad++ shortcuts. There is also a column editor,Alt+C, which allows you to replace the text selected in column mode with either some text, or with incrementing numbers in various bases.

Note that it is possible to mark a column selection of zero width, but it becomes invisible when you do so. A zero width block is useful with the column editor if you wish to insert some text without replace any existing text.

If you wish to select a very long column block that extends over many pages (for example, in a very long file), this might be the best technique:

• Click to position the cursor at the top left corner of the desired block.
  
• Scroll down to the desired end of the block by any means (page down, control+end, drag the vertical scroll bar, etc).
  
• Hold down alt+shift and click on the bottom right corner of the desired block.

本文轉自
http://npp-community.tuxfamily.org/faq