使用Word的COM元件。

Word._Application app = new Word.ApplicationClass();   
app.Visible = false;
    
object nothing = System.Reflection.Missing.Value;
object temp = Environment.CurrentDirectory + @"/resume.doc";   //文件模板

Word.Document doc = app.Documents.Open(ref temp,ref nothing,ref nothing,ref nothing,
       ref nothing,ref nothing,ref nothing, ref nothing, ref nothing,
       ref nothing,ref nothing,ref nothing,ref nothing,ref nothing,ref nothing,ref nothing);//開啟模板

doc.Tables[1].Cell(1,2).Range.Text  = ""; // 給單元格新增內容

//給單元格插入圖片
doc.Tables[1].Cell(1,5).Range.InlineShapes.AddPicture(ImgPath,ref nothing,ref nothing,ref nothing);